The San Francisco 49ers (6-10) take a three-game losing streak into a matchup against the Arizona Cardinals (7-9) on Sunday, January 5, 2025 at State Farm Stadium. Arizona is a 4.5-point favorite in the game.
NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 10:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Cardinals vs. 49ers game info Game day: Sunday, January 5, 2025 Game time: 4:25 p.m. ET TV channel: FOX Location: Glendale, Arizona Stadium: State Farm Stadium Live stream: Watch this game on Fubo Watch Cardinals vs. 49ers on Fubo! Cardinals vs. 49ers odds & betting lines Spread favorite: Arizona (-4.5) Moneyline: Arizona (-207), San Francisco (+172) Total: 42.5 points More NFL odds Ravens vs. Browns odds Bengals vs. Steelers odds Commanders vs. Cowboys odds Packers vs. Bears odds Colts vs. Jaguars odds Bills vs. Patriots odds Eagles vs. Giants odds Buccaneers vs. Saints odds Titans vs. Texans odds Falcons vs. Panthers odds Cardinals vs. 49ers recent matchups Over the last five matchups between Arizona and San Francisco, the 49ers are 4-1. In those matchups with the Cardinals, the 49ers went 4-1 against the spread, and those games outscoring the total on four occasions. San Francisco outscored Arizona 179-92 in the five head-to-head matchups between the two teams. Cardinals vs. 49ers betting insights Arizona is 10-6-0 against the spread so far this season. The Cardinals have been listed as moneyline favorites six times this season, and they have recorded a 2-4 record in those games. San Francisco has won five games against the spread this season (5-11-0). The 49ers have been an underdog on the moneyline three times so far this season, and they lost every game. Cardinals scoring insights The Cardinals are averaging more points at home (24.1) than away (20.0). Defensively, Arizona is giving up 18.6 points per game at home, less than its 25.8 average on the road. The Cardinals average fewer points in division games (19.6) than against the rest of the league (23.2). Arizona has conceded 18.4 points per game in the division, which is better than its average in non-division games of 23.9. Looking at the Cardinals' last three contests, they have posted 23.0 points per game on offense (16th-ranked) and have allowed 22.0 points per game on defense (15th-ranked). 49ers scoring insights At home, the 49ers' scoring average is 25.3 points per game, which is better than their average on the road (19.6). On defense, San Francisco is giving up 21.4 points per game at home, better than its 28.0 average away from home. On offense, the 49ers are scoring 21.2 points per game in divisional contests, which is less than their 23.5 average versus the rest of the league. San Francisco is allowing 21.4 points per game in divisional matchups, which is lower than its 25.6 average in non-division games. In terms of points scored, including the past three games only, the 49ers are 22nd in the NFL (19.0 per game). On the flip side they are 24th in points conceded (27.0). Cardinals injury report Cardinals:
Sean Murphy-Bunting: Limited Participation in Practice (Toe),
Kelvin Beachum: Did Not Participate In Practice (Knee),
Hjalte Froholdt: Full Participation in Practice (Personal),
Mack Wilson: Limited Participation in Practice (Ankle),
Darius Robinson: Limited Participation in Practice (Calf),
Matt Prater: Limited Participation in Practice (Knee)
49ers injury report 49ers:
Talanoa Hufanga: Full Participation in Practice (Wrist),
Isaac Guerendo: Full Participation in Practice (Foot),
Ji'Ayir Brown: Did Not Participate In Practice (Ankle),
Ricky Pearsall: Limited Participation in Practice (Illness),
Isaac Yiadom: Limited Participation in Practice (Pelvis),
Deommodore Lenoir: Did Not Participate In Practice (Shoulder),
George Kittle: Limited Participation in Practice (Ankle),
Deebo Samuel: Did Not Participate In Practice (Ribs),
Nick Bosa: Did Not Participate In Practice (Knee),
Colton McKivitz: Did Not Participate In Practice (Knee),
Leonard Floyd: Did Not Participate In Practice (Shoulder),
Robert Beal Jr.: Did Not Participate In Practice (Ankle),
Brock Purdy: Did Not Participate In Practice (Elbow),
Demetrius Flannigan-Fowles: Did Not Participate In Practice (Calf),
Spencer Burford: Did Not Participate In Practice (Calf)
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