Angela Dugalic added 13 points and 14 rebounds for her second double-double for the Bruins (12-0, 1-0 Big Ten), whose stingy defense made Creighton's top shooters uncomfortable.
Morgan Maly scored 15 points to lead the Bluejays (9-3, 1-0 Big East), whose eight-game winning streak was snapped.
The 6-foot-7 Betts sat out a second straight game with a leg injury she sustained against Long Beach State on Dec. 14. She averages team-bests of 19.8 points and 10.0 rebounds.
Creighton leading scorer Lauren Jensen was held to four points on 2-of-15 shooting after coming into the game averaging 19.1 points.
Creighton: Creighton was 1 for 13 in the opening quarter, missing all five of its 3s to fall behind in a hurry and finishing 5 of 22 from deep. The Bluejays are 0-4 in the series, having lost to UCLA in the second round of last season's NCAA Tournament, 67-63.
UCLA: Rice shot 8 for 13 and also had five rebounds and four assists. Freshman guard Elina Aarnisalo increased her team-leading assists total to 63 through the first 12 games of her collegiate career.
UCLA shot 11 for 22 in the opening quarter -- 4 of 6 from 3-point range -- to jump to a 26-4 lead.
UCLA held a commanding 59-26 rebounding advantage -- 29-12 in the first half on the way to a 42-23 lead at the break. Janiah Barker grabbed 11.